Exactmer specializes in cutting-edge technologies for the precise manufacturing of exact, sequence-defined polymers in liquid phase, addressing sustainability challenges in oligonucleotide and peptide synthesis. Our primary mission is to reduce high manufacturing costs and overcome the scale limitations of solid-phase methods. At the core of this effort is Nanostar Sieving™, an indefinitely scalable liquid-phase polymer synthesis platform that surpasses the constraints of classical solid-phase synthesis. This breakthrough technology enables precise polymer purification by organic solvent nanofiltration (OSN, Fig.1), currently at scales ranging from 1 to 60 mmol of final product.

The chemistry-agnostic nature of Exactmer’s approach allows broad adaptability across various markets, including oligonucleotides, peptides, and pharmaceutical polymers such as PEGs [1]. The key to Nanostar Sieving separation is the use of membrane diafiltration in strong organic solvents. The membranes are made of chemically robust crosslinked polybenzimidazole (PBI) [2], ensuring exceptional stability in organic solvents and harsh reaction conditions. Apart from the removal of removal reaction debris, diafiltration is also an effective tool for drying reaction mixtures prior to water-sensitive coupling reactions, without energy-intensive evaporation techniques.

Exactmer is committed to reducing the need for traditional column chromatography and to improving the process mass intensity through solvent recycling, acid-free protection chemistry, and advanced membrane-based purification methods. By integrating scalable liquid-phase synthesis with efficient, sustainable purification, we are redefining polymer manufacturing, enhancing efficiency, scalability, and environmental sustainability.

References

1. M.J. Burggraef, A. Oxley, N.A. Zaidi, P.R. Cutillas, P.R. J. Gaffney, A. G. Livingston Nature Comm. 2024, 15, 9814.
2. A. Oxley, P.R.J. Gaffney, D. Kim, P. Marchetti, A.G. Livingston J. Membrane Sci. 2022, 647, 120199.